Serial Experiments Lain does not explicitly feature identifiable LGBTQ+ characters or themes. The series' complex narrative centers on philosophical and technological concepts, exploring identity and reality through its protagonist, Lain, without delving into specific sexual orientations or gender identities.

Serial Experiments Lain explores complex themes of identity, reality, and the digital self. The narrative does not feature identifiable transsexual characters or themes. The show's focus on identity fluidity pertains to the blurring of physical and digital existence and the nature of consciousness, rather than gender identity or transition.

The movie does not contain any action or adventure elements.

Serial Experiments Lain is an original anime series. All characters are new creations for this specific show, meaning there is no prior canon or source material from which a character's gender could have been swapped.

Serial Experiments Lain is an original anime series from 1998. All characters were created for this specific production and do not have prior canonical or historical racial establishments to deviate from. Therefore, no race swaps occurred.