The Afterparty features Hannah in Season 2, an LGBTQ+ character whose unrequited love for her adopted sister, Grace, is a central emotional and plot element. Her queer identity and feelings are depicted with dignity, complexity, and empathy, avoiding negative stereotypes. The show's portrayal is affirming, treating her character and emotions respectfully within the narrative.

The show portrays a devout Christian character, Jennifer, with respect and sympathy, highlighting her kindness and moral integrity. While a character's music video satirizes religious hypocrisy, the narrative frames this as a critique of the character's superficiality rather than the faith itself.