The O.C. features a notable storyline where a main character, Marissa Cooper, explores a same-sex relationship. This depiction is handled with respect, avoiding harmful stereotypes or demonization. However, the relationship is temporary, and the character ultimately moves on, preventing the portrayal from being a strong, lasting affirmation of queer identity. The net impact is therefore neutral.

The show portrays Christianity as a foundational cultural element, often blended with other traditions (like Judaism in "Chrismukkah") in a positive, inclusive manner. While some characters may exhibit superficiality, the faith itself is not depicted negatively, and its traditions are shown as sources of comfort and community.

Judaism is depicted positively through characters like Seth and Sandy Cohen, serving as a source of strong family identity, tradition, and moral values. The show celebrates its practices, particularly through the "Chrismukkah" tradition, emphasizing cultural blending and acceptance.