The Ren & Stimpy Show, a cartoon known for its surreal and often gross-out humor, does not include any identifiable transsexual characters or themes throughout its episodes. The series primarily focuses on the misadventures of its two main characters, Ren and Stimpy, without engaging with transgender identity.

The show primarily features male protagonists and supporting characters. Female characters are generally minor and are not depicted engaging in or winning close-quarters physical combat against male opponents.

The Ren & Stimpy Show is an original animated series. All characters were created for this show, meaning there are no pre-existing canonical characters from other source material whose gender could have been swapped.

The Ren & Stimpy Show is an original animated series, meaning its characters were created for this specific production. There is no prior source material or historical record from which characters' races could have been established and subsequently changed.