Big Fat Liar does not feature any explicit LGBTQ+ characters or themes. The film's plot centers on a high school student's efforts to expose a dishonest Hollywood producer, with no elements related to queer identity appearing in the story or character portrayals.

Big Fat Liar does not feature any identifiable transsexual characters or themes. The film's plot and character arcs are entirely unrelated to transsexual identity or experiences, resulting in no depiction of these elements.

The film is a comedy focused on pranks and schemes rather than physical combat. No female characters are depicted engaging in or winning close-quarters physical fights against male opponents through skill or strength.

Big Fat Liar is an original film with characters created specifically for this production. There are no pre-existing canonical or historical characters whose gender could have been altered.

Big Fat Liar is an original film with characters created specifically for this production. There is no prior source material, historical basis, or previous installments from which character races could be established and subsequently changed.