Godzilla vs. Megaguirus is a kaiju film centered on monster battles and a scientific defense against Godzilla. Its narrative focuses on military operations and scientific endeavors, and it does not include any discernible LGBTQ+ characters or themes.

Godzilla vs. Megaguirus is a kaiju film centered on the conflict between Godzilla and the insect monster Megaguirus. The narrative focuses on action, science fiction elements, and military strategy, and does not include any identifiable transsexual characters or themes.

The film primarily focuses on kaiju battles and human characters operating advanced military technology. No female characters are depicted engaging in or winning close-quarters physical combat against one or more male opponents. The main female character, Kiriko Tsujimori, leads a special forces unit and operates weaponry, but does not participate in hand-to-hand combat.

The film introduces new human protagonists and a new kaiju, Megaguirus, without drawing from prior characters with established genders. Godzilla, a returning character, maintains his historically male portrayal. Therefore, no characters undergo a gender swap.

This Japanese kaiju film features original human characters who are consistently portrayed by Japanese actors, aligning with the film's origin and the broader franchise's typical character depictions. No established character from prior canon or source material has their race altered.