Resident Evil: Degeneration does not feature any identifiable LGBTQ+ characters or themes within its narrative. The film's focus is entirely on its action-horror plot involving bioterrorism and survival, with no elements related to queer identity or experiences.

Resident Evil: Degeneration does not feature any identifiable transsexual characters or explore themes related to transgender identity. The film's plot is centered on action, horror, and the established lore of the Resident Evil universe.

The film features female characters Claire Redfield and Angela Miller who participate in combat. However, their victories are primarily achieved using firearms against zombies and mutated biological weapons, not through close-quarters physical combat against human male opponents.

The film features established characters like Leon S. Kennedy and Claire Redfield, whose genders remain consistent with their original portrayals in the Resident Evil game series. New characters introduced in the film do not have prior canonical genders to swap from.

The film features established characters Leon S. Kennedy and Claire Redfield, both of whom are depicted as white, consistent with their prior canonical appearances. All other significant characters are original to this film and thus do not have a pre-existing race to be swapped from.