Mr. Peabody & Sherman does not feature any identifiable LGBTQ+ characters or themes. The film's plot centers on time travel and the relationship between a genius dog and his adopted human son, with no elements pertaining to queer identity.

Mr. Peabody & Sherman is an animated film centered on time travel and the bond between a dog and his adopted son. The story does not feature any identifiable transsexual characters or explore related themes. Consequently, the film has no discernible impact on the portrayal of transsexual identity.

The film features female characters such as Penny Peterson, Marie Antoinette, and Ms. Grunion. However, none of these characters engage in or win close-quarters physical combat against one or more male opponents using skill, strength, or martial arts. Penny's scuffle with Sherman is a child's fight, not a combat feat.

The film adapts characters from "Peabody's Improbable History." The two main legacy characters, Mr. Peabody and Sherman, retain their original male genders. No established characters from the source material underwent a gender change in this adaptation.

The animated film "Mr. Peabody & Sherman" (2014) adapts characters from the 1960s cartoon. All human characters, including Sherman and Penny, are depicted as the same race (white) as their original animated counterparts. Mr. Peabody is an anthropomorphic dog, so race is not applicable. No race swaps were identified.