The film offers a net positive portrayal of LGBTQ+ characters. Big Gay Al is a well-adjusted and affirming figure, while the prominent same-sex relationship between Satan and Saddam, though abusive, critiques the abuser rather than the relationship's nature, ultimately showing Satan's growth and agency.

The film strongly critiques Christian fundamentalism, moral panic, and the use of religious rhetoric to justify censorship, war, and violence. It portrays adherents of this extreme viewpoint as foolish, hypocritical, and dangerous, with no significant counterbalancing positive portrayal of the faith itself.

While a Jewish character (Sheila Broflovski) is a primary antagonist, her negative portrayal stems from her personal flaws and role in the moral panic, not from her Jewish faith. Kyle, a Jewish protagonist, is a sympathetic and often rational character.