The Last Voyage of the Demeter does not feature any explicit LGBTQ+ characters or themes. The film is a horror story centered on a ship's crew battling a vampire, with its narrative solely focused on survival and supernatural elements. Consequently, there is no portrayal of the LGBTQ+ community to evaluate.

The Last Voyage of the Demeter does not feature any identifiable transsexual characters or explore themes related to gender identity. The film's genre and plot are centered on horror and survival, leaving no room for such depictions. Consequently, the movie has no impact, positive or negative, on the portrayal of transsexual individuals or communities.

The movie does not contain any action or adventure elements.

The film's main characters, including Clemens, Anna, Captain Eliot, and Dracula, are portrayed with the same genders as established in their canonical source material, with no instances of on-screen gender changes.

The film adapts Bram Stoker's Dracula, where the races of characters like Clemens and Joseph were not specified in the source material. Anna is a new character created for the film. Therefore, the casting of actors of diverse ethnicities for these roles does not meet the definition of a race swap, which requires a character to be canonically established as one race and then portrayed as another.