The series "Nancy Drew" offers a positive portrayal of LGBTQ+ characters, primarily through Bess Marvin, who is openly bisexual and later lesbian. Her identity and relationships are depicted with dignity, complexity, and emotional depth, seamlessly integrated into the narrative without tokenism or negative framing. The show affirms the worth of queer lives and love.

The show 'Nancy Drew' includes a trans woman character, Amanda, who is depicted with dignity and respect. Her identity is affirmed by those around her, and she is given agency and a storyline that avoids harmful stereotypes, contributing to a positive overall portrayal.

The 2019 "Nancy Drew" series features several core characters, including George Fayne, Bess Marvin, and Ned Nickerson, who were canonically white in the original book series but are portrayed by actors of different races.