One Day at a Time provides a profoundly positive and affirming portrayal of LGBTQ+ characters and themes. Through Elena's coming-out arc and her relationship with Syd, the show depicts queer identity with dignity, complexity, and agency. It consistently champions acceptance and love, framing challenges as external and promoting a supportive environment.

One Day at a Time features Syd, a non-binary character, depicted with dignity and complexity. The narrative portrays the Alvarez family's journey of learning and acceptance regarding Syd's identity and pronouns, framing any initial misunderstandings as opportunities for growth. The overall portrayal is affirming and respectful, highlighting a healthy, supportive relationship.

The 2017 reboot of "One Day at a Time" features Alex Alvarez, a male character, in a role that corresponds to Barbara Cooper, a female character in the original 1975 series. This constitutes a gender swap.

The 2017 reboot reimagines the core family from the original 1975 series, changing their race from white to Cuban-American. This constitutes a race swap for the main characters.

The show portrays Catholicism, particularly through Lydia, as a vital source of cultural identity, comfort, and community. While individual characters may question or struggle with their faith, the narrative consistently treats it with respect, highlighting its positive influence and dignity.