The Simpsons has evolved to include openly LGBTQ+ characters like Patty Bouvier and Waylon Smithers, depicting their identities with increasing dignity and complexity. While earlier humor could be stereotypical, the show's overall trajectory has been towards acceptance, integrating these characters respectfully into the narrative and exploring their personal lives.

The show portrays Buddhism positively, notably through Lisa Simpson's exploration of the faith. It highlights its tenets of peace, compassion, and spiritual seeking as a valid and respectful path.

The show frequently satirizes the hypocrisy and institutional flaws within Christianity, particularly through characters like Reverend Lovejoy. However, it also portrays devout and morally upright characters like Ned Flanders, and often critiques bigotry against faith, ultimately presenting a nuanced view that affirms the positive aspects of community and personal belief despite human failings.

Hinduism, primarily through Apu Nahasapeemapetilon, is depicted as an integral and respected part of a sympathetic character's identity. While some cultural aspects are played for humor, the faith itself is not portrayed negatively, but rather as a source of strength and community.

While not a central focus, Islam is generally depicted with respect, often highlighting cultural differences rather than condemning the faith. The show avoids portraying it as inherently problematic, focusing instead on individual characters or cultural exchange.

Judaism is portrayed with respect and nuance, primarily through Krusty the Clown and his father, Rabbi Krustofski. The narrative explores themes of tradition, family, and identity, often with emotional depth, without ridiculing the faith itself.