2001: A Space Odyssey does not feature any identifiable LGBTQ+ characters or themes. The narrative is centered on philosophical and scientific concepts, and human relationships are not explored through an LGBTQ+ lens.

2001: A Space Odyssey does not feature any identifiable transsexual characters or themes. The film's narrative is centered on humanity's evolution, artificial intelligence, and existential questions, without engaging with transgender identity or experiences.

The film does not feature any female characters engaging in direct physical combat. There are no scenes depicting a female character defeating one or more male opponents through skill, strength, or martial arts in close-quarters combat.

The film's main characters, including David Bowman, Frank Poole, and Dr. Heywood Floyd, maintain the same gender as established in Arthur C. Clarke's source material. There are no instances of a character canonically established as one gender being portrayed as a different gender.

The film's main characters, such as Dr. David Bowman, Dr. Frank Poole, and Dr. Heywood Floyd, are portrayed by actors whose race aligns with their descriptions in the source novel and the original conception of the characters. There are no instances where a character canonically established as one race is depicted as a different race.