The film 'Up in Smoke' does not feature any identifiable LGBTQ+ characters or themes. Its narrative focuses on the misadventures of two stoner protagonists, with no elements related to queer identity or experiences present in the plot or character arcs.

The film "Up in Smoke" does not feature any identifiable transsexual characters or themes. The narrative focuses on the comedic misadventures of its main characters, Cheech and Chong, without engaging with topics of gender identity or transsexuality.

The film "Up in Smoke" is a comedy that does not feature any female characters engaging in or winning direct physical combat against male opponents. Female roles are not depicted in action-oriented capacities within the movie.

Up in Smoke is an original film from 1978, not an adaptation of existing material or a reboot. All characters were created for this movie, meaning there is no prior canonical or historical gender to establish a baseline for comparison. Therefore, no gender swaps occur.

This film is an original production and not an adaptation of pre-existing material or a biopic. All characters were created for this movie, meaning there are no prior canonical or historical racial portrayals to compare against. Therefore, no race swaps occurred.