The show features Dutch Velders, a bisexual main character whose sexual orientation is depicted factually and respectfully. Her identity is integrated naturally into her character and relationships, without being a central theme or source of conflict. The portrayal neither uplifts nor denigrates LGBTQ+ identity, maintaining a neutral stance.

The character Dutch, a hacker who was male in the original novel series, is portrayed as a female character named Dutch Velders in the television adaptation.

The series portrays Judaism through Abraham Setrakian, a Holocaust survivor whose Jewish heritage and historical understanding are central to his righteous fight against the strigoi. The narrative affirms his perspective as crucial to understanding and combating the ancient evil.