Truth Be Told features prominent LGBTQ+ characters, including Poppy's lesbian sister, Lanie, and gay friend, Markus. Their identities are depicted with dignity and complexity, integrated naturally into the narrative without being a source of mockery or negative stereotypes. The show normalizes their relationships and lives, contributing to an overall affirming portrayal.

Truth Be Told Season 3 features Eva, a Black trans woman, as a central character whose experiences as a sex worker are integral to the main investigation. The show portrays her with dignity and complexity, highlighting the specific vulnerabilities faced by trans women of color due to external societal issues. The narrative's empathetic stance and focus on systemic injustices result in a net positive portrayal of trans themes.

The series 'Truth Be Told' adapts the novel 'Are You Sleeping,' where the protagonist Poppy Scoville and several family members and other characters were canonically white. In the show, these characters are portrayed by Black actors, constituting multiple instances of race swapping.

The series portrays Christianity as a significant aspect of several characters' lives, offering moral guidance, community, and a path to redemption. While individual adherents may exhibit flaws or hypocrisy, the narrative does not condemn the faith itself, but rather the actions of individuals.